A rational design approach to peat ground improvement by vertical drains

A stochastic approach to automated design improvement

The object-oriented approach to software development facilitates and encourages programming practices that increase reusability, correctness and maintainability in code. This is achieved in Java by providing mechanisms for inheritance, abstraction and encapsulation. By measuring properties that indicate to what extent these mechanisms are utilised we can determine to a large extent how good a d...

Drug Design—A Rational Approach

Drug design may be considered as an integrated whole approach which essentially involves various steps, namely : chemical synthesis, evaluation for activity-spectrum, toxicological studies, metabolism of the drug, i.e., biotransformation and the study of the various metabolites formed, assay procedures, and lastly galenical formulation and biopharmaceutics. The ‘drug design’ in a broader sense ...

Drug Design—A Rational Approach

In the past few decades there has been a hiatus in the momentum of research and discovery of ‘novel’ medicinal compounds. This particular trend in drug development perhaps is augmented due to two vital factors, namely : first, strict empirical and rational approach to drug design ; and secondly, high standards of safety and therapeutic efficacy together with tremendous increased costs of resear...

Soft soils improved by prefabricated vertical drains: performance and prediction

Improvement of the soy formate dehydrogenase properties by rational design.

Previous experiments on substitution of the residue Phe290 to Asp, Asn and Ser in NAD(+)-dependent formate dehydrogenase from soya Glycine max (SoyFDH) showed important role of the residue in enzyme thermal stability and catalytic properties (Alekseeva et al. Prot. Eng. Des. Sel., 2012a; 25: :781-88). In this work, we continued site-directed mutagenesis experiments of the Phe290 and the residue...